Former champion Stan Wawrinka fell victim to a final-set fade as the 2015 winner was taken down 2-6, 6-3, 6-3, 4-6, 6-0 on Friday at the French Open by a local wild card.
Hugo Gaston remains the final home hope at Roland Garros after his rain-interrupted victory; the 20-year-old is the last of 18 Frenchman who began the week at the clay-court major.
The No. 239 winner is the lowest-ranked player to reach the round of 16 here since another French wild card, No. 283 Arnaud di Pasquale, in 2002.
The defeat was the heaviest ever for the Swiss seed, who had never been beaten at a Grand Slam by an opponent ranked so low.
The contest was interrupted at 2-all in the second set for several hours by rain with the pair having split sets.
When they came back out, the experienced wawrinka was unable to gain full control and just went away in the final set.