YANINA WICKMAYER (BEL #146) vs. [2] SOFIA KENIN (USA #4)

Wickmayer leads 1-0 Wickmayer won when the two met at a WTA 125K Series event two years ago… Kenin fell early at last week’s Western & Southern Open… Wickmayer made SF here in New York back in 2009

KRISTIE AHN (USA #96) vs. [3] SERENA WILLIAMS (USA #8)

First meeting Williams is one of only two women to record more than 100 wins at the US Open… Ahn made Slam breakthrough by reaching last 16 here in 2019… Williams coming off early exit at Western & Southern Open

[5] ARYNA SABALENKA (BLR #11) vs. OCEANE DODIN (FRA #115)

First meeting Sabalenka produced best Grand Slam result to date with fourth-round run at 2018 US Open… Dodin owns two Top 20 wins in her career… Sabalenka is seeded for the seventh straight Slam

[7] MADISON KEYS (USA #14) vs. TIMEA BABOS (HUN #101)

Keys leads 3-1 Keys beat the Hungarian en route to finals at Rome and Birmingham in 2016… Babos posted best result at a major with third-round run here in 2016… Keys was runner-up to Stephens in 2017’s all-American final

HEATHER WATSON (GBR #54) vs. [9] JOHANNA KONTA (GBR #13)

Konta leads 3-0 Konta won pair’s most recent encounter at 2018 Nottingham in two tight sets… Former junior champion Watson has never won a singles match in the women’s draw… Konta made QF here 12 months ago

NAO HIBINO (JPN #78) vs. [10] GARBIÑE MUGURUZA (ESP #16)

Muguruza leads 2-0 Muguruza dropped a combined total of four games across their two previous encounters back in 2016… Hibino has fallen at the first hurdle eight times in 10 Slam appearances… Muguruza playing 30th major

[20] KAROLINA MUCHOVA (CZE #26) vs. VENUS WILLIAMS (USA #67)

First meeting Williams is one of six former champions in the draw… Muchova made third round here in 2018… Williams bidding to become third woman in her 40s to win a US Open singles match

[WC] KIM CLIJSTERS (BEL #N/A) vs. [21] EKATERINA ALEXANDROVA (RUS #29)

First meeting Clijsters lifted title here as a wildcard in 2009… Alexandrova beat former US Open champion Stosur in first round here last year… Clijsters looking for first match win since returning to the tour

VIKTORIYA TOMOVA (BUL #133) vs. [22] AMANDA ANISIMOVA (USA #28)

First meeting Anisimova is the highest-ranked of 11 teenagers in the draw… Tomova owns one Top 50 win in her career… Anisimova was junior champion here in 2017

[26] SLOANE STEPHENS (USA #39) vs. MIHAELA BUZARNESCU (ROU #122)

First meeting Stephens won the title at Flushing Meadows ranked No.83 in 2017… Buzarnescu returning to the tour after a long-term shoulder injury… Stephens has lost five times to players outside Top 100 in 2020

VICTORIA AZARENKA (BLR #27) vs. BARBARA HAAS (AUT #139)

First meeting Azarenka embarking upon 50th Grand Slam main draw of career… Haas meanwhile is contesting only her second… Azarenka fresh from collecting 21st singles title of her career

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