[1] KAROLINA PLISKOVA (CZE #3) vs. CAROLINE GARCIA (FRA #50)

Series tied 3-3 Pliskova won their only Grand Slam meeting at 2017 Roland Garros… Garcia was runner-up in the juniors here in 2011… Pliskova has reached the last 16 or better on her past four appearances in New York

[4] NAOMI OSAKA (JPN #9) vs. CAMILA GIORGI (ITA #74)

Osaka leads 1-0 Osaka overcame the Italian en route to 2018 Tokyo final… Giorgi recovered from 5-3 down in final set to beat Van Uytvanck on Monday… Osaka has lost twice to players ranked outside Top 50 so far in 2020

KATERYNA KOZLOVA (UKR #99) vs. [6] PETRA KVITOVA (CZE #12)

First meeting Kvitova’s first-round win was her 107th at Slam level… Kozlova attempting to reach third round at a major for the first time… US Open is only Grand Slam where Kvitova has failed to reach SF

KATERYNA BONDARENKO (UKR #349) vs. [8] PETRA MARTIC (CRO #15)

Bondarenko leads 2-1 Martic won when the two met most recently at 2017 Roland Garros… Bondarenko is one of seven mothers in the draw… Martic enjoying her highest seeding at a Slam

[11] ELENA RYBAKINA (KAZ #17) vs. SHELBY ROGERS (USA #93)

First meeting Rybakina has won a tour-leading 22 matches in 2020… Rogers bidding to reach third round here for a third time… Rybakina playing just third main draw tournament on US soil

ANN LI (USA #128) vs. [13] ALISON RISKE (USA #20)

Riske leads 1-0 Riske beat Li in straight sets on grass at Surbiton last summer… Li fell to Kenin in second round at Australian Open in January… Riske dropped just five games in quick-fire first-round win

KAJA JUVAN (SLO #113) vs. [14] ANETT KONTAVEIT (EST #21)

First meeting Juvan struck 35 winners during straight-set first-round win… Kontaveit made Grand Slam breakthrough with run to last 16 here in 2015… Juvan one of 11 teenagers in the starting field

[17] ANGELIQUE KERBER (GER #23) vs. ANNA-LENA FRIEDSAM (GER #109)

Kerber leads 2-0 Kerber won comfortably when they played in first round at 2018 Australian Open… Friedsam through to second round in New York for the first time… Kerber playing her milestone 50th major this fortnight

MADISON BRENGLE (USA #84) vs. [19] DAYANA YASTREMSKA (UKR #25)

First meeting Yastremska pushed hard by Sharma in opening round… Brengle’s opening round win was first at Flushing Meadows since 2015… Yastremska’s coach Sacha Bajin helped Naomi Osaka to 2018 US Open title

[WC] CICI BELLIS (USA #188) vs. [28] JENNIFER BRADY (USA #40)

Bellis leads 1-0 Bellis won when the two clashed in qualifying at 2018 Sydney… Brady seeded for the first time at a Slam, on her 13th appearance at this level… On Monday, Bellis won her first US Open match in four years

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