[1] Novak Djokovic (SRB) vs Kyle Edmund (GBR) Djokovic Leads 5-1
[4] Stefanos Tsitsipas (GRE) vs [WC] Maxime Cressy (USA) First Meeting

[WC] Brandon Nakashima (USA) vs [5] Alexander Zverev (GER) First Meeting
[12] Denis Shapovalov (CAN) vs Soonwoo Kwon (KOR) First Meeting

[32] Adrian Mannarino (FRA) vs Jack Sock (USA) Sock Leads 4-1
Gilles Simon (FRA) vs [19] Taylor Fritz (USA) Simon Leads 1-0

• Eight Americans return to action on Wednesday after posting impressive first-round wins on Monday.
[19] Taylor Fritz – World No. 25
1R – Rallied from a set down to defeat Dominik Koepfer, who reached 2019 US Open 4R
2R – Faces former World No. 6 Gilles Simon with chance for 4th Grand Slam 3R appearance
Steve Johnson – World No. 64
1R – Earned 5th straight H2H win over [16] John Isner, defeating No. 1 American in 5th-set tiebreak
2R – Faces fellow 30-year-old Ricardas Berankis, who is ranked one spot lower than him at No. 65
Marcos Giron – World No. 96 (Career-High)
1R – Rallied from 2-sets-to-1 down to defeat Marc Polmans for 1st Grand Slam win in 5th attempt
2R – Meets [26] Filip Krajinovic and seeks back-to-back wins for 2nd time in career (2019 Indian Wells)
[WC] Maxime Cressy – World No. 168
1R – Joined fellow former UCLA Bruin Marcos Giron in 2R by winning tour-level debut over Jozef Kovalik
2R – Meets [4] Stefanos Tsitsipas, who is 18-0 in tour-level matches against players outside Top 120
[WC] Michael Mmoh – World No. 186
1R – Defeated former Top-30 player Joao Sousa for 1st US Open win in 3rd attempt
2R – Meets [28] Jan-Lennard Struff with chance to reach Grand Slam 3R for 1st time
[WC] Mitchell Krueger – World No. 198
1R – Capitalized on 2nd tour-level WC of 8-year career, beating Pedro Sousa for 1st Grand Slam win
2R – Seeks biggest win of career against No. 20 seed and World No. 27 Pablo Carreno Busta
[WC] Brandon Nakashima – World No. 223
1R – 19-year-old won Grand Slam debut against Paolo Lorenzi, who reached 2017 US Open 4R
2R – Hopes to become youngest American to reach US Open 3R since Donald Young, 18, in 2007
[PR] Jack Sock – World No. 389
1R – Defeated Pablo Cuevas in 5th-set tiebreak, avenging loss to Uruguayan in 2019 US Open 1R
2R – Hopes to become lowest-ranked player in US Open 3R since No. 475 Tommy Haas in 2011