Amanda Anisimova sent an ominous message to the competition as she blew away American Bernarda Pera on Wednesday 6-2 6-0.
The match was moved to court Philippe Chatrier after Serena Williams withdrew from the tournament.
Anisimova will meet either world No.1 Simona Halep or Irina-Camelia Begu in the next round.
She beat Halep in straight sets in the quarter-finals last year.